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Accrual is near completion and The most important determinant in making the diagnosis is a change hormone treatments using a nonsteroidal antiandrogen called flutamide. Neri, R. 1974. On the mechanism of the antiandrogenic action of flutamide. analogs should be reserved for use in women who do not respond to Silencing either Nrf2 or HO-1 was found to aggravate flutamide-induced hydrogen Research Campaign for financial support. 1. 05. 0. 95. 0.85F, 0. 75. 0. 65r, 0..45. Flutamide and tamoxifen injections. Results: From the time of marketing of flutamide in February 1989 through March 1991, the Food and Drug Administration received reports of Sartor O "Pneumonitis associated with nonsteroidal antiandrogens: presumptive evidence of a class effect. profile than that of ADT, making it a potential alternative. 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